Diurnal Variation in and Optimal Time to Measure Holter-Based Late Potentials to Predict Lethal Arrhythmia after Myocardial Infarction

نویسندگان

چکیده

Background and Objectives: Holter-based late potentials (LPs) are useful for predicting lethal arrhythmias in organic cardiac diseases. Although LPs exhibit diurnal variation, no studies have evaluated the optimal timing of LP measurement over 24 h arrhythmia that leads to sudden death. Thus, this study aimed validate most effective testing explore factors influencing variability parameters. Materials Methods: We retrospectively analyzed 126 patients with post-myocardial infarction (MI) status 60 control participants who underwent high-resolution Holter electrocardiography. Among post-MI patients, 23 developed sustained ventricular tachycardia (VT) (the MI-VT group), while 103 did not MI-non-VT group) during observation period. were measured at 0:00, 4:00, 8:00, 12:00, 16:00, 20:00, heart rate analysis was simultaneously performed investigate Results: parameters showed variation significant deterioration night improvement day. Assessment time longest duration low-amplitude signals < 40 μV filtered QRS complex terminus (LAS40) gave highest receiver operating characteristics curve (area under curve, 0.659) odds ratio (3.75; 95% confidence interval, 1.45–9.71; p = 0.006) VT. In multiple regression analysis, noise affecting groups. non-VT group, significantly influenced by parasympathetic parameters, such as logpNN50. Conclusions: For measurements, test accuracy higher when or worst value LAS40. Changes autonomic nervous system activity, including rate, variability. Increased activity bradycardia may exacerbate

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ژورنال

عنوان ژورنال: Medicina-lithuania

سال: 2023

ISSN: ['1010-660X', '1648-9144']

DOI: https://doi.org/10.3390/medicina59081460